Research Capabilities

Research Capabilities

Molecular Design & Synthesis Core Laboratory

Contact

David Augeri, Ph.D.
Director
david.augeri@pharmacy.rutgers.edu
848-445-6493

The Molecular Design & Synthesis Core Laboratory focuses on the design and synthesis of small molecule probes of new biology. In collaboration with other biomedical scientists, Prep LCMS-2these probes are used to interrogate biological pathways to create preliminary data for grant applications as well as to design molecules for diagnostic and therapeutic use. The Molecular Design & Synthesis core has established research collaborations with biotech companies as well as with internal Rutgers University partners in multiple departments including RBHS and CINJ.

  • Molecular Design by interpretation of structure-activity relationships (SAR)
  • Synthesis of a wide variety of chemotypes (heterocyclic and chiral synthesis)
  • Advanced synthesis including microwave reaction capability
  • LC/MS to monitor reaction progress and outcome
  • Normal phase and reverse phase mass directed HPLC purification
  • NMR structure determination (500 MHz, 400 MHz spectrometers)
  • Analytical HPLC for purity determination, 98% standard
  • Synthesized compounds as crystalline solids or lyophilized salts

 

Molecular Imaging Center

Contact

Ed Yurkow, Ph.D.
Executive Director
yurkow@vpr.rutgers.edu
848-445-1405

MIC Website
imaging.rutgers.edu

The Molecular Imaging Center provides a non-invasive approach to study various biological and disease models in living systems and ex vivo organs. Molecular Imaging CenterOur comprehensive imaging modalities for the basic sciences include:

The facility allows researchers to generate multiple, spatially-resolved anatomical, functional, and molecular-level readouts from a single study. Image reconstruction, 3D display and quantitative image analysis are also available.  The Center provides animal holding facilities for serial imaging, anesthesia, surgery and veterinary care.  In addition to consultation and experimental service, the Center offers periodic training and conducts research to improve existing imaging technologies. Our mission is to empower Rutgers users by promoting independent utilization of the facility and to provide imaging resources to other organizations. 

 

Research Pathology Services

Contact

Michael Goedken, D.V.M., Ph.D.
Director
michael.goedken@rutgers.edu

The Research Pathology Services team supports animal model research with a range of histology techniques and knowledge of comparative pathophysiology to ensure Prep LCMS-2appropriate experimental design and results interpretation. Services provided include:

  • Necropsy
  • Tissue trimming and processing
  • Routine and special stains
  • Publication quality images
  • Morphometric analysis
  • Results interpretation
    • Histology
    • Immunohistochemistry
    • Electron microscopy
    • Clinical pathology
  • Document review for optimal pathology content
    • Experimental design
    • Grant proposals
    • Manuscripts